Endocrine Abstracts

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

Secondary hormonal deficiency (SHD) in sellar masses (SM) is thought to be partly due to compression of the portal vessels by the enlarging tumour restricting the blood supply to the normal pituitary tissue. However, to date no study has looked at the patterns of SHD in various types of SM and assessed if SHD is related solely to the size of SM or is associated with the underlying pathology. We assessed 914 patients with SM enrolled in our comprehensive pituitary registry sinc...

Background: Despite the widespread use of the 250-μg Cosyntropin test (ACTH test) for the diagnosis of adrenal insufficiency (AI), the effect of timing of the test on 30- vs. 60-min serum cortisol values remains unclear. Also, there is limited evidence comparing the value of performing both 30- and 60-min cortisol levels.Methods: We conducted a retrospective cohort study of all ACTH tests conducted at the Halifax Neuropituitary Program, Nova Scotia,...

Background: Acromegaly (Acro) is associated with adverse psychopathological and personality outcomes despite being in remission for over a decade. We hypothesised that persistently poor psychological outcomes may be associated with morphometric changes experienced by Acro patients.Methodology: We compared 60 consecutive non-functioning adenoma (NFA) and Acro patients who had undergone pituitary surgery and/or radiation therapy (RT). A gender-specific vis...

We recently developed a visual scale to assess the extent of morphometric changes in Acromegaly (Acro) patients which is strongly predictive of adverse psychological outcomes. We sought to identify if there was any association between the self-drawing test and the visual morphometric scale and if there was any correlation with psychological outcomes.We compared 60 consecutive non-functioning adenoma (NFA) and Acro patients who had undergone pituitary sur...

Background: Individuals with hypoparathyroidism often experience a range of symptoms associated with reduced health-related quality of life (HRQoL) and work productivity. Conventional therapy aims to alleviate hypocalcemia and acute symptoms but fails to restore normal parathyroid hormone (PTH) physiology or improve HRQoL. In the PaTHway trial, 79% of participants treated with TransCon PTH vs. 5% placebo (P<0.0001) met the primary efficacy endpoint (normal serum c...